Description
PK profiles are similar to typical oral dosage; and compared these two formulations to IV dose (square) given at 200 mg. All the Instruction for this Homework is in the excal sheet. PLEASE ONLY USE this excel I’m not allowed to post from other souces. Before you start: Use Excel only (no other format). No copying and posting fomual or graph into excal ; Must show numbers and calculations in Excel that are traceable.
Unformatted Attachment Preview
In real PK study, data is not as smooth as shown in Textbook. Humans show variations which are typical.
In this study, Scientists studied 2 different formulations, 300 mg strength (Open and Closed Circles) and P
and compared these two formulations to IV dose (square) given at 200 mg. Drug levels were measured u
The graph is shown from the literature. You should study (look to see what is going on) and deal with it.
Why do you need to look at the graph: You will reproduce the part of the graph with PK model(s) and com
Dosage:
Time mins
5
10
20
25
30
40
50
60
65
80
90
110
120
160
180
200
220
240
300
360
380
460
480
Suppository
300 mg
S mg/L
0.15
0.6
1.25
1.35
1.6
Oral Tablet 300 mg
IV 200 mg
T mg/L
IV mg/L
0.07
0.55
0.8
1.35
0.6
1.09
1.9
1.89
1.55
0.8
0.65
1.4
1.1
1.05
0.36
0.28
0.7
0.6
0.2
0.17
0.2
0.07
0.9
0.76
0.63
0.55
0.4
0.33
0.2
0.1
0.065
0.12
0.04
Before you start:
Use Excel only (no other format).
No copying and posting into excel allowed.
Must show numbers and calculations in Excel that are traceable. Only do all your work in this excel sheet.
Question 1. (Score 9 points). Please show how you got your answer
Fill in the table (show in your excel). Must show in EXCEL how did you get the values and write the units.
Suppository
Dosage:
Oral Tablet 300 mg
300 mg
Ka
Constant
2
R
Kel
Constant
R2
Question 2:
a. Write model equation for Cp vs Time: 1 point.
Suppository
Tablet
IV
a. Explain which parameter is same (within expt error) for all 3 dosages. 1point.
b. Graph model vs actual data for all 3 dosages,( there should be two graph shown here.one for th
Question 3:
1. Fill in the table (show in your excel). Must show how did you get the values and the units. Sco
Dosage:
Suppository
300 mg
Oral Tablet 300 mg
Tmax
Cmax
AUC 0-480 min
Bioavailability F
1. Which dosage form, suppository or tablet, should be developed for Clinical stu
2. Based on which parameters did you base your answer 3.2. Score 1 point.
w variations which are typical.
en and Closed Circles) and PK profiles are similar to typical oral dosage;
Drug levels were measured up to 8 hours (480 minutes) in humans and average values are shown.
s going on) and deal with it.
ph with PK model(s) and compare model to data as part of your answer in this Homework.
is excel sheet.
Conc mg/L
plotted on semi
FYI Excel or 123 were not i
write the units.
IV 200 mg
ges. 1point.
o graph shown here.one for the Model and one for the data (9 points).
he values and the units. Score 8 points
IV 200 mg
be developed for Clinical study? Score 1 point .
swer 3.2. Score 1 point.
Conc mg/L
plotted on semi-log paper.
FYI Excel or 123 were not invented 1970’s
Purchase answer to see full
attachment
