Description
1. What determines a toxicant compound’s environmentally harmful concentrations?
2. Define dose-response relationship. What is a dose-response curve?
3. Describe the two parameters of a dose-response curve, which determine the curve.
4. Similar slopes of dose-response curves may imply about what the xenobiotics are being compared? 5. Discuss the two prevailing concepts for studying toxicity of compounds at low concentrations.
6. What are the most important parameters when choosing statistical design parameters for a toxicity test?
7. What evaluation method for laboratory toxicity data is more appropriate for estimating environmen- tal effects than the midpoint in a dose-response curve? Why is it more appropriate?
8. List the 5 drawbacks of hypothesis testing (in determining the NOEL and LOEL) as compared to curve-fitting models, as per Stephan and Rogers?
9. Why does a regression method (modeling) provide superior information for characterizing toxic responses?
10. What is the optimum design strategy of toxicity tests for the use of the regression method?
11. What are the critical design considerations for multispecies toxicity tests?
12. Why are univariate toxicity tests not always appropriated for microcosm studies?
